Invasive Fungal Infections Secondary to Traumatic Injury.

Invasive fungal infection (IFI) is a rare but serious complication of traumatic injury. The purpose of this article is to review the epidemiology, natural history, mycology, risk factors, diagnosis, treatment, and outcomes associated with post-traumatic IFI in military and civilian populations.

The epidemiology of post-traumatic IFI is poorly characterized, but incidence appears to be rising. Patients often suffer from severe injuries and require extensive medical interventions. Fungi belonging to the order Mucorales are responsible for most post-traumatic IFI in both civilian and military populations. Risk factors differ between these cohorts but include specific injury patterns and comorbidities.

Diagnosis of post-traumatic IFI typically follows positive laboratory results in the appropriate clinical context. The gold standard of treatment is surgical debridement in addition to systemic antifungal therapy. Patients with post-traumatic IFI may be at greater risk of amputation, delays in wound healing, hospital complications, and death as compared to trauma patients who do not develop IFI.

EpiQuik Superoxide Dismutase Activity/Inhibition Assay Kit (Colorimetric)
OP-0001	EpiGentek	5x96 assays	EUR 496.6
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FEED-0001	Creative Enzymes	1kg	EUR 227

Rabbit anti-Rift Valley Fever (RVFV) antiserum
01-0001	IBT Bioservices	250uL	EUR 451
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Rabbit anti-Rift Valley Fever (RVFV) pAb
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Monkey Alpha 1 Microglobulin ELISA kit
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Monkey Alpha 1 Microglobulin ELISA kit
E09α0001-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Monkey Alpha 1 Microglobulin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

More research is needed to understand the factors surrounding the development and management of post-traumatic IFI to reduce the significant morbidity and mortality associated with this disease.