In this review, we describe the epidemiology and clinical significance of resistance in Candida spp. and other non-Cryptococcus yeasts.
The rise in echinocandin resistance, azole resistance and cross-resistance to two or more antifungal classes [multidrug resistance (MDR)] has been a worrisome trend, mainly in US large tertiary and oncology centres, particularly as it relates to Candida glabrata. Candida kefyr is also a concern as it can be resistant to echinocandins and polyenes, especially in patients with haematological malignancies.
Lately, Candida auris has drawn a lot of attention: this uncommon Candida spp. is the first globally emerging fungal pathogen that exhibits MDR and strong potential for nosocomial transmission. Its almost simultaneous spread in four continents could be indicative of increasing selection pressures from the use of antifungal agents. Echinocandin non-susceptibility is also common among non-Candida, non-Cryptococcus yeasts.
) EpiQuik Nuclear Extraction Kit II (Nucleic Acid-Free) |
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| OP-0022 | EpiGentek | 100 Extractions | EUR 292.15 |
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Description: kits suitable for this type of research |
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 Native Bacteria Achromopeptidase |
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| NATE-0022 | Creative Enzymes | 1g | EUR 475 |
 Affinipure) Donkey Anti-Goat IgG (H+L) Affinipure |
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| FNSA-0022 | FN Test | 500 uL | EUR 341.4 |
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Description: Donkey Anti-Goat IgG (H+L) Affinipure secondary antibody |
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 Human complement factor D,CFD ELISA Kit |
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| 201-12-0320 | SunredBio | 96 tests | EUR 440 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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) ELISA kit for PGI2 (Prostacyclin) |
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| E-EL-0022 | Elabscience Biotech | 1 plate of 96 wells | EUR 377 |
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Description: A competitive ELISA kit for quantitative measurement of PGI2 (Prostacyclin) in samples from Serum, Plasma, Cell supernatant |
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) Fast-Pfu with 10mM dNTP Mix (250U) |
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| 9K-001-0022 | Bio Basic | 250U | EUR 402.35 |
) 2X Pfu PCR Premix (5 x 1mL) |
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 Human thyroxine,T4 ELISA Kit |
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| 201-12-0022 | SunredBio | 96 tests | EUR 440 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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As Candida resistance patterns reflect, in part, institutional practices of antifungal administration, the benefits of antifungal stewardship protocols are increasingly recognised and endorsed in recent guidelines. Development of rapid diagnostic methods for detecting or ruling out the presence of candidaemia and antifungal resistance, as well as discovery of novel antifungals, are key priorities in medical mycologyresearch.